Officers found the snakes as well as mice and rats while searching the Santa Ana house after neighbors complained about the smell of something rotten, police Cpl. Anthony Bertagna said.
"The smell alone - I feel like I need to take a shower for a week," Bertagna said. "They're pretty much in all the bedrooms - everywhere."
The pythons were kept throughout the five-bedroom house.
William Buchman, a 53-year-old teacher in Newport Beach, was arrested for investigation of neglect in the care of animals, Bertagna said.
Animal control authorities had tried to work with Buchman for several months after neighbors reported the smell but sought a warrant after they were not allowed inside the home where Buchman lived alone, Bertagna said.
Efforts to reach Buchman were not immediately successful. A message was left seeking comment at Newport-Mesa Unified School District.